Semax is a synthetic heptapeptide derived from the 4–10 fragment of adrenocorticotropic hormone (ACTH), extensively studied for its neuroprotective, nootropic, and neurotrophic properties. For a deeper scientific overview of the compound's mechanism, see our Semax research overview. For researchers in Malaysia studying BDNF signalling, cerebral ischaemia, or cognitive performance, Semax is now accessible locally through Concept Peptides without the complications of international ordering.
Note: Semax supplied by Concept Peptides is a research-grade compound intended strictly for laboratory and preclinical research purposes. It is not for human consumption. Researchers requiring Semax for clinical or licensed medical use should approach their institutional pharmacy or a licensed pharmaceutical distributor.
What Makes Semax Different
ACTH-Derived Design
Semax is built on the ACTH(4-10) fragment — a sequence known since the work of David de Wied and colleagues to enhance attention, memory consolidation, and stress resilience without triggering the steroidogenic effects of full-length ACTH. Researchers at the Institute of Molecular Genetics of the Russian Academy of Sciences appended a Pro-Gly-Pro tripeptide extension to this scaffold, substantially improving metabolic stability and duration of action compared with the native fragment.
BDNF Upregulation
Among the most significant findings in Semax research is its ability to increase brain-derived neurotrophic factor (BDNF) expression in the brain. BDNF is essential for neuronal survival, synaptic plasticity, and the consolidation of memories in the hippocampus. Research has shown Semax administration elevates BDNF mRNA and protein levels in rodent brain regions including the hippocampus, basal forebrain, and frontal cortex — a mechanism considered central to its cognitive and neuroprotective effects.
Neuroprotection in Ischaemia Models
Semax has been extensively studied in rodent models of cerebral ischaemia, including middle cerebral artery occlusion — a standard preclinical stroke model. Research has associated Semax administration with reduced infarct volume, improved neurological function scores, reduced post-ischaemic oedema, and enhanced hippocampal neurogenesis following injury.
How to Buy Semax in Malaysia
Local vs Overseas Sourcing
Semax research peptide sourced from overseas typically arrives in 3–5 weeks and involves customs risk. As a Malaysia-based supplier, Concept Peptides ships Semax domestically with 1–3 business day delivery and no import complications. Every product is accompanied by a third-party Certificate of Analysis confirming sequence accuracy and purity.
What Format Is It Supplied In?
Concept Peptides supplies Semax as a lyophilised (freeze-dried) powder in a sealed 10mg research vial. Lyophilisation preserves stability and extends shelf life prior to reconstitution. It is reconstituted with BAC Water prior to use. A free BAC Water vial is included with every Semax order.
Purity Verification
Every product is independently tested by a third-party laboratory and a Certificate of Analysis (COA) is available upon request, confirming the amino acid sequence, molecular weight, and purity percentage by HPLC.
Semax COA (Janoshik Test Report)
The Certificate of Analysis on our Semax product page is a Janoshik Analytical test report for batch JP20260038 (task #223591, analysed 23 August 2026). It measured 10.44 mg of Semax in a 10 mg vial at 99.231% purity. You can verify it at janoshik.com/verify using the key W934MQLPGEJ3.
Frequently Asked Questions
What is Semax used for in research?
Semax is used in preclinical and research settings to study ACTH(4-10)-derived neuropeptide activity — particularly its effects on BDNF expression, neuroprotection following cerebral ischaemia, cognitive performance, and stress resilience in animal models.
Where can I buy Semax in Malaysia?
Research-grade Semax is not sold in pharmacies or retail stores in Malaysia. Concept Peptides is a Malaysia-based supplier stocking Semax in lyophilised research-grade format, with local payment methods and domestic shipping throughout Malaysia — order via WhatsApp or through the product page directly.
Is Semax available in Malaysia?
Yes — Concept Peptides stocks Semax in lyophilised research-grade format, available for order with local payment methods and domestic shipping throughout Malaysia, strictly for research and laboratory use.
How does Semax compare to Selank?
Semax is an ACTH(4-10)-derived peptide studied primarily for BDNF upregulation, neuroprotection, and cognitive enhancement, while Selank is a synthetic analogue of tuftsin studied mainly for anxiolytic and immunomodulatory effects. Both are heptapeptides developed by Russian researchers and are often studied together in cognitive and stress-resilience research. For the full mechanism of the anxiolytic compound, see our Selank research overview, and for sourcing details see our guide to buying Selank in Malaysia.
How should it be stored after arrival?
Lyophilised Semax should be stored at -20°C for long-term stability. If the vial will be used within 4–6 weeks, storage at 2–8°C is acceptable. Once reconstituted with BAC water, store the solution at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles of the reconstituted preparation.
References
- Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Miasoedov NF, Rayevsky KS. "Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents." Neurochemical Research. 2005;30(12):1493–1500.